The Smart Toxin Formula

We believe the purity and performance of the product matter. That’s why we take the time to double filter our smart toxin with a proprietary XTRACT Technology™ process.

Built different for a reason

Other toxins contain unnecessary ingredients that can lead to treatment resistance over time. Ours doesn’t. We filter out all the unnecessary ingredients, leaving you with a one of a kind, purified injectable. Ask your provider why purity matters.

ABOUT XEOMIN

What’s in your toxin?

XEOMIN contains only what you need. It filter out all unnecessary ingredients so you get only what’s needed for treating your frown lines, forehead lines, and crow’s feet, resulting in the consistent, natural look you love.

Effectiveness without excess

Before photo taken before frown line injection. Individual results may vary. Before and after photos taken at maximum frown. Xeomin is a temporary treatment.

Chronic Sialorrhea in Adult Patients:

The recommended total dose per treatment session is 100 Units. XEOMIN is injected into the parotid and submandibular glands on both sides (i.e., 4 injection sites per treatment session). The recommended total dose per treatment session is 100 Units. The dose is divided with a ratio of 3:2 between the parotid and submandibular glands.

Use the following guidelines if locating salivary glands using anatomic landmarks:
1) To inject the parotid gland, find the midpoint on the line connecting the tragus and mandible angle, approximately at the height of the ear lobe. Deliver the injection one finger breadth anterior to this site.

2) To inject the submandibular gland, find the midpoint between the angle of the mandible and the tip of the chin. Deliver the injection one finger breadth medial to the inferior surface of the mandible at this site.

Chronic Sialorrhea in Pediatric Patients:

XEOMIN is injected into the parotid and submandibular glands on both sides (i.e., 4 injection sites per treatment session). Ultrasound imaging is recommended to guide needle placement into the salivary glands. The body-weight adjusted dose is divided with a ratio of 3:2 between the parotid and submandibular glands. XEOMIN has not been studied in children weighing less than 12 kg.

The maximum recommended dose of XEOMIN for simultaneous treatment of upper facial lines [i.e., glabellar lines (GL), horizontal forehead lines (HFL) and lateral canthal lines (LCL)] in adult patients is 64 Units, comprised of 20 Units for GL, 20 Units for HFL, and 24 Units for LCL.

Administer retreatment with XEOMIN no more frequently than every three months.

When not treating upper facial lines (GL, HFL, and LCL) simultaneously in adult patients, refer to the following instructions:

Glabellar Lines

Equally distribute GL treatment to five equal intramuscular injections of 4 Units each. Inject 4 Units of reconstituted XEOMIN intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in the procerus muscle for a maximum recommended dose of 20 Units.
To reduce the complication of ptosis take the following steps:

  • Avoid injection near the levator palpebrae superioris, particularly in patients with larger brow depressor
    complexes.
  • Place corrugator injections at least 1 cm above the bony supraorbital ridge.

Horizontal Forehead Lines in Conjunction with Glabellar Lines

Treat HFL in conjunction with GL to minimize the potential for brow ptosis. The maximum recommended dose for treatment of HFL (20 Units) in conjunction with GL (20 Units) is 40 Units.

Equally distribute HFL treatment to 5 horizontally orientated intramuscular injection sites (4 Units each) into the frontalis muscle, at least 2 cm above the orbital rim.

Lateral Canthal Lines

Inject 4 Units of reconstituted XEOMIN into 3 sites per side (6 total injection sites) in the lateral orbicularis oculi muscle for a total of 12 Units per side (24 Units overall). Place one injection in the horizontal extension of the lateral canthus approximately 1 cm lateral from the bony orbital rim. Place the other two injections approximately 1 cm above and below the area of the first injection. Give injections with the needle bevel tip up and oriented away from the eye. Avoid injections too close to the zygomaticus major muscle to prevent lip ptosis.

The recommended dose of XEOMIN for cervical dystonia ranges from 120 Units to 240 Units given intramuscularly as a divided dose among affected muscles. In previously treated patients, consider their past dose, response to treatment, duration of effect, and adverse event history when determining the XEOMIN dose.
In the treatment of cervical dystonia, XEOMIN is usually injected into the sternocleidomastoid, levator scapulae, splenius capitis, scalenus, and/or the trapezius muscle(s). This list is not exhaustive, as any of the muscles responsible for controlling head position may require treatment.Tailor the dose and number of injection sites in each treated muscle to the individual patient based on the number and location of the muscle(s) to be treated, the degree of spasticity/dystonia, muscle mass, body weight, and response to any previous botulinum toxin injections.
Determine the frequency of XEOMIN repeat treatments by clinical response, but administer repeat treatments no more frequent than every 12 weeks.

FREQUENTLY ASKED QUESTIONS

WHAT IS XEOMIN®?
Xeomin® (incobotulinumtoxinA) is a prescription medication injected into muscles and used to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines) in adults. Xeomin® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.
HOW DOES XEOMIN® WORK?
When you squint or frown, the muscles between your eyebrows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines. Botulinum toxin type A – the active ingredient in Xeomin®– acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, Xeomin® can temporarily reduce the lines between your eyebrows.
IS XEOMIN® PROVEN?
Xeomin® was proven effective in two randomized, double-blind, multicenter, placebo-controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years. Patients received 20 Units of Xeomin® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment success was higher with Xeomin® than placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, Xeomin® received FDA approval for use in glabellar lines in 2011.
WHAT SHOULD I TELL MY DOCTOR BEFORE TREATMENT?
Before receiving treatment with Xeomin®, you should tell your doctor about all of your medical conditions, including whether you have a disease that affects your muscles and nerves, have allergies to any botulinum toxin product, or have experienced any side effect from any other botulinum toxin in the past. In addition, tell your doctor about your medical history and all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you have received any other botulinum toxin product in the last four months or in the past. Be sure your doctor knows exactly which product(s) you received and when you received them.
WHAT CAN I EXPECT DURING TREATMENT?
During treatment, which usually takes about 10-20 minutes, your doctor will inject Xeomin® into the muscles in your forehead that cause frown lines between your eyebrows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.
HOW DO I KNOW IF XEOMIN® IS RIGHT FOR ME?
If you are an adult with moderate to severe glabellar lines, Xeomin® may be right for you. Talk to your doctor to discuss the benefits and risks of treatment. Do not use Xeomin® if you are allergic to botulinum toxin or any of the other ingredients in Xeomin®. You should also not use Xeomin® if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.
WHEN CAN I EXPECT TO SEE THE RESULTS
You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.
WHAT ARE THE MOST COMMON SIDE EFFECTS OF XEOMIN®?
Xeomin® may cause serious side effects, including allergic reactions. Symptoms of an allergic reaction to Xeomin® may include: itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or seek medical help right away if you have wheezing, experience other asthma symptoms, or if you become dizzy or faint.In clinical trials of Xeomin® for the treatment of frown lines between the eyebrows, headache was the most common side effect. Xeomin® may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of taking Xeomin®. If this happens, do not drive a car, operate machinery, or do other dangerous activities. Tell your doctor if you have any side effect that bothers you or that does not subside. These are not all of the possible side effects of Xeomin®. For more information, see accompanying Full Prescribing Information including Medication Guide, or ask your doctor.
ARE YOU CONCERNED WITH LOOKING PLASTIC OR OVERDONE?
Looking plastic or overdone is a common concern among individuals considering an in-office treatment for moderate to severe frown lines.* Talk to your licensed, trained, healthcare professional. There are steps you can take to make you feel more comfortable. First, have a detailed discussion with your provider. You want to talk through every concern you have, until you feel comfortable. Your provider, who is experienced in facial anatomy, can determine the right options for you. For example, the most widely used procedure for moderate to severe frown lines is neurotoxin injections, a class of prescription medication that has been shown to be effective in many studies. Finally, ask for an FDA-approved product, such as Xeomin®. Individual results may vary.

VISIT XEOMIN WEBSITE TO LEARN MORE ABOUT IT!