
ABOUT XEOMIN
What’s in your toxin?
XEOMIN contains only what you need. It filter out all unnecessary ingredients so you get only what’s needed for treating your frown lines, forehead lines, and crow’s feet, resulting in the consistent, natural look you love.
Effectiveness without excess
Before photo taken before frown line injection. Individual results may vary. Before and after photos taken at maximum frown. Xeomin is a temporary treatment.
Chronic Sialorrhea in Adult Patients:
The recommended total dose per treatment session is 100 Units. XEOMIN is injected into the parotid and submandibular glands on both sides (i.e., 4 injection sites per treatment session). The recommended total dose per treatment session is 100 Units. The dose is divided with a ratio of 3:2 between the parotid and submandibular glands.
Use the following guidelines if locating salivary glands using anatomic landmarks:
1) To inject the parotid gland, find the midpoint on the line connecting the tragus and mandible angle, approximately at the height of the ear lobe. Deliver the injection one finger breadth anterior to this site.
2) To inject the submandibular gland, find the midpoint between the angle of the mandible and the tip of the chin. Deliver the injection one finger breadth medial to the inferior surface of the mandible at this site.

Chronic Sialorrhea in Pediatric Patients:
XEOMIN is injected into the parotid and submandibular glands on both sides (i.e., 4 injection sites per treatment session). Ultrasound imaging is recommended to guide needle placement into the salivary glands. The body-weight adjusted dose is divided with a ratio of 3:2 between the parotid and submandibular glands. XEOMIN has not been studied in children weighing less than 12 kg.

The maximum recommended dose of XEOMIN for simultaneous treatment of upper facial lines [i.e., glabellar lines (GL), horizontal forehead lines (HFL) and lateral canthal lines (LCL)] in adult patients is 64 Units, comprised of 20 Units for GL, 20 Units for HFL, and 24 Units for LCL.
Administer retreatment with XEOMIN no more frequently than every three months.
When not treating upper facial lines (GL, HFL, and LCL) simultaneously in adult patients, refer to the following instructions:
Glabellar Lines
Equally distribute GL treatment to five equal intramuscular injections of 4 Units each. Inject 4 Units of reconstituted XEOMIN intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in the procerus muscle for a maximum recommended dose of 20 Units.
To reduce the complication of ptosis take the following steps:
- Avoid injection near the levator palpebrae superioris, particularly in patients with larger brow depressor
complexes. - Place corrugator injections at least 1 cm above the bony supraorbital ridge.
Horizontal Forehead Lines in Conjunction with Glabellar Lines
Treat HFL in conjunction with GL to minimize the potential for brow ptosis. The maximum recommended dose for treatment of HFL (20 Units) in conjunction with GL (20 Units) is 40 Units.
Equally distribute HFL treatment to 5 horizontally orientated intramuscular injection sites (4 Units each) into the frontalis muscle, at least 2 cm above the orbital rim.
Lateral Canthal Lines
Inject 4 Units of reconstituted XEOMIN into 3 sites per side (6 total injection sites) in the lateral orbicularis oculi muscle for a total of 12 Units per side (24 Units overall). Place one injection in the horizontal extension of the lateral canthus approximately 1 cm lateral from the bony orbital rim. Place the other two injections approximately 1 cm above and below the area of the first injection. Give injections with the needle bevel tip up and oriented away from the eye. Avoid injections too close to the zygomaticus major muscle to prevent lip ptosis.

The recommended dose of XEOMIN for cervical dystonia ranges from 120 Units to 240 Units given intramuscularly as a divided dose among affected muscles. In previously treated patients, consider their past dose, response to treatment, duration of effect, and adverse event history when determining the XEOMIN dose.
In the treatment of cervical dystonia, XEOMIN is usually injected into the sternocleidomastoid, levator scapulae, splenius capitis, scalenus, and/or the trapezius muscle(s). This list is not exhaustive, as any of the muscles responsible for controlling head position may require treatment.Tailor the dose and number of injection sites in each treated muscle to the individual patient based on the number and location of the muscle(s) to be treated, the degree of spasticity/dystonia, muscle mass, body weight, and response to any previous botulinum toxin injections.
Determine the frequency of XEOMIN repeat treatments by clinical response, but administer repeat treatments no more frequent than every 12 weeks.

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